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During the autoimmune-resistant pressure, activating Xist in bioengineered male mice wasn’t plenty of to induce autoimmunity — as is likely to be predicted by The actual fact that in this strain even females seldom establish autoimmunity. That indicates that not only Xist activation but in addition an acceptable genetic qualifications is necessary for autoimmunity to create.
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In these prone mice, males by which the Xist gene was activated formulated lupus-like autoimmunity in a rate approaching that of females — and considerably more so than non-bioengineered males.
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But Xist itself is manufactured only once the X chromosome that its gene resides on is one of a matched XX pair— and is produced and deployed on only one member of that pair.
Early in embryogenesis, Every single mobile from the nascent female mammal will make an unbiased conclusion to shut down the exercise of 1 or another of its two X chromosomes. After that selection is created, it’s handed down to these cells’ progeny within the creating fetus. That way, exactly the same quantity of Every X-chromosome-specified protein is produced inside a female cell as in a male mobile.
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